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DI02 Genetic SNP Test




Effects of thyroid hormones are determined by many factors beyond their serum levels. These effects are difficult to examine by traditional techniques, but a novel approach that exploits the existence of common genetic variants has yielded new and surprising insights. Studies have shown that thyroid hormones and iodine deficiency contribute to osteoarthritis, hypertension, IQ, psychological well-being and response to T(3) or T(4) treatment.


Intriguingly, most of these associations are independent of serum thyroid hormone levels, which highlights the importance of local regulation of thyroid hormones in tissues.


Studies suggest that a commonly inherited variation in the DIO2 gene is associated both with impaired baseline psychological well-being on T(4) and enhanced response to combination T(4)/T(3) therapy, but did not affect serum thyroid hormone levels.


This simple buccal swab genetic test evaluates a polymorphism related to the DI02 gene.


SKU: REG-GEN-DI02 Categories: , ,

Additional Information

Further reading:
Nat Rev Endocrinol. 2009 Apr;5(4):211-8. doi: 10.1038/nrendo.2009.19. Novel insights into thyroid hormones from the study of common genetic variation. Dayan CM1, Panicker V.
J Clin Endocrinol Metab. 2009 May;94(5):1623-9. doi: 10.1210/jc.2008-1301. Epub 2009 Feb 3.
Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. Panicker V1, Saravanan P, Vaidya B, Evans J, Hattersley AT, Frayling TM, Dayan CM.



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